Skin Collagen Literature Update
2022 – 2024
Reilly DM, Kynaston L, Naseem S, Proudman E, Laceby D. A Clinical Trial Shows Improvement in Skin Collagen, Hydration, Elasticity, Wrinkles, Scalp, and Hair Condition following 12-Week Oral Intake of a Supplement Containing Hydrolysed Collagen. Dermatol Res Pract. 2024 Jul 10;2024:8752787. doi: 10.1155/2024/8752787. PMID: 39021368; PMCID: PMC11254459
A supplement containing hydrolysed collagen and vitamin C has shown clinical benefits for skin, scalp, and hair, when used either daily or every 48 hours, over a 12-week period
The results of this study show that freshwater fish-derived liquid collagen can be used as a healthy functional food ingredient to improve skin moisturizing, anti-wrinkling, and elasticity in an aging population.
Lee JS, Yoon YC, Kim JM, Kim YH, Kang YH, Shin YC. Liquid collagen from freshwater fish skin ameliorates hydration, roughness and elasticity in photo- aged skin: a randomized, controlled, clinical study. Nutr Res Pract. 2024 Jun;18(3):357-371. doi: 10.4162/nrp.2024.18.3.357. Epub 2024 May 17. PMID: 38854476; PMCID: PMC11156766
Dierckx S, Patrizi M, Merino M, González S, Mullor JL, Nergiz-Unal R. Collagen peptides affect collagen synthesis and the expression of collagen, elastin, and versican genes in cultured human dermal fibroblasts. Front Med (Lausanne). 2024 May 1;11:1397517. doi: 10.3389/fmed.2024.1397517. PMID: 38751975; PMCID: PMC11094247
[This study] provide cell-based evidence for the beneficial effects of exposure to collagen peptides on the skin’s collagen content and on the molecules that provide firmness and elasticity. This may support the hypothesis that collagen peptides are important for maintaining extracellular matrix (ECM) structure and skin regeneration.
[The study] consistently demonstrated substantial enhancements in skin moisture levels and elasticity compared to the placebo group, a trend robustly corroborated by subgroup analysis. These compelling findings underscore the effectiveness of a 12-week regimen of hydrolyzed collagen supplementation in revitalizing the skin by augmenting its hydration and elasticity.
Dewi DAR, Arimuko A, Norawati L, Yenny SW, Setiasih NL, Perdiyana A, Arkania N, Nadhira F, Wiliantari N. Exploring the Impact of Hydrolyzed Collagen Oral Supplementation on Skin Rejuvenation: A Systematic Review and Meta-Analysis. Cureus. 2023 Dec 9;15(12):e50231. doi: 10.7759/cureus.50231. PMID: 38192916; PMCID: PMC10773595
Pu SY, Huang YL, Pu CM, Kang YN, Hoang KD, Chen KH, Chen C. Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis. Nutrients. 2023 Apr 26;15(9):2080. doi: 10.3390/nu15092080. PMID: 37432180; PMCID: PMC10180699
The findings of this study revealed that [hydrolyzed collagen] supplementation can improve skin hydration and elasticity. In addition, the long-term use of collagen yields more favorable effects on skin hydration and elasticity than the short-term use of collagen.
Compared with the placebo group, skin desquamation, hydration, skin wrinkling, and elasticity were significantly improved after 4, 4, 12, and 12 weeks of administration, respectively
Lee M, Kim E, Ahn H, Son S, Lee H. Oral intake of collagen peptide NS improves hydration, elasticity, desquamation, and wrinkling in human skin: a randomized, double-blinded, placebo-controlled study. Food Funct. 2023 Apr 3;14(7):3196-3207. doi: 10.1039/d2fo02958h. PMID: 36916504.
Samadi A, Movaffaghi M, Kazemi F, Yazdanparast T, Ahmad Nasrollahi S, Firooz A. Tolerability and efficacy assessment of an oral collagen supplement for the improvement of biophysical and ultrasonographic parameters of skin in middle eastern consumers. J Cosmet Dermatol. 2023 Aug;22(8):2252-2258. doi: 10.1111/jocd.15700. Epub 2023 Mar 13. PMID: 36912494.
The study demonstrated that oral collagen peptides could significantly improve the skin elasticity, roughness, and dermis echo density, and they also proved to be safe and well-tolerated.
This study showed that the oral supplementation of low-molecular-weight collagen peptides could improve the wrinkles, elasticity, hydration, and barrier integrity of photoaged facial skin
Kim J, Lee SG, Lee J, Choi S, Suk J, Lee JH, Yang JH, Yang JS, Kim J. Oral Supplementation of Low-Molecular-Weight Collagen Peptides Reduces Skin Wrinkles and Improves Biophysical Properties of Skin: A Randomized, Double-Blinded, Placebo-Controlled Study. J Med Food. 2022 Dec;25(12):1146-1154. doi: 10.1089/jmf.2022.K.0097. PMID: 36516059
Oral dietary supplements, including collagen, ceramides, hyaluronan, and procyanidin, were proven to be effective for skin moisturization.
Sun Q, Wu J, Qian G, Cheng H. Effectiveness of Dietary Supplement for Skin Moisturizing in Healthy Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Front Nutr. 2022 Jun 2;9:895192. doi: 10.3389/fnut.2022.895192. PMID: 35719159; PMCID: PMC9201759.
